GLENDALE, Ariz. – Linebacker Tatum Bethune quickly nixed any comparisons between Arizona Cardinals tight end Trey McBride and 49ers counterpart George Kittle. “Nah, nah, not at all. George, nobody is similar to George,” Bethune said. “George is a unicorn.”

Sunday's showdown in the desert will feature two teams that are coming off tough losses.

When these two faced back in Week 3, it was 49ers’ backup quarterback Mac Jones outlasting the Cardinals’ starting quarterback Kyler Murray in a 16-15 San Francisco victory. The roles will be reversed as Brock Purdy will make his first start since Week 4 against Jacoby Brissett, who will be making his fifth start since replacing the injured Murray.

Dominating the trenches, disciplined defense and a potent run game are critical for the 49ers to bounce back against the Cardinals.