The Buffalo Bills have been one of the NFL's most impressive teams through the season's first two weeks despite minimal contributions from their 10-member draft class.

The Buffalo Bills are one of just eight 2-0 teams in the NFL, with the gap between them and the Super Bowl-favorite Rams shrinking as September progresses.

NFL Week 3 score predictions, picks, betting odds for Buffalo Bills vs Los Angeles Chargers game on Sunday, Sept. 27, 2026. Who will win NFL game?

The Buffalo Bills are looking to hand the Los Angeles Chargers an 0-3 start as huge home favorites ahead of their 1 p.m. ET kickoff at Highmark Stadium on Sunday, Sept. 27. My early Chargers vs. Bills predictions and NFL picks are calling for Buffalo to cover the number while holding the Los Angeles offense in check in Week 3.

The Bills are expected to play the Canadian national anthem, along with "The Star Spangled Banner," before their home games in the 2026 season. While the Bills are technically the only team that plays in New York, since the Giants and Jets play their games in New Jersey, the team isn't regarded as a New York team like the other two are.

The Buffalo Bills bring in a powerful defensive tackle capable of pushing the pocket in a new 2027 NFL mock draft from Todd McShay.

The Buffalo Bills' quarterback avoided a potential serious injury in Week 1, and the NFL has further penalized the offender.