The Chargers entered the season with top odds to win the AFC. Things have changed.

The Chargers can't cover and can't rush the passer through two games, and the path to fixing those issues remains unclear.

The Buffalo Bills are looking to hand the Los Angeles Chargers an 0-3 start as huge home favorites ahead of their 1 p.m. ET kickoff at Highmark Stadium on Sunday, Sept. 27. My early Chargers vs. Bills predictions and NFL picks are calling for Buffalo to cover the number while holding the Los Angeles offense in check in Week 3.

Week 2 in the NFL was short on fireworks but long on fallout. Here are the biggest winners and losers from Sunday's games.

The Los Angeles Chargers failed to learn from their Week 1 defeat against the Arizona Cardinals and once again came up short in Week 2, suffering a disappointing 26-14 loss to the Las Vegas Raiders on Sunday.

Week two of the NFL season has the Raiders heading to LA to face the Chargers on Sunday. Here's how to catch the game on TV and streaming.

NFL Week 3 score predictions, picks, betting odds for Buffalo Bills vs Los Angeles Chargers game on Sunday, Sept. 27, 2026. Who will win NFL game?

The Chargers mustered just 14 points vs. the Raiders, which is confounding for a team led by Jim Harbaugh, Mike McDaniel and Justin Herbert.

Nate Tice and Hayden Winks dive into instant reactions from Week 2 of the NFL season.