Proteins and peptides form the cornerstone of cellular function, serving not only as essential catalysts and structural components but also as mediators of signalling and regulation in health and ...

A new LMU study shows how proteins function reliably even without a stable 3D structure – and the crucial importance not only of short sequence motifs, but also of the chemical characteristics. Many ...

In a recent study published in the journal Nature Machine Intelligence, researchers developed "DeepGO-SE," a method to predict gene ontology (GO) functions from protein sequences using a large, ...

An illustration of one of Grove Biopharma’s protein-like polymers in sky blue and bright yellow. These protein-like polymers may help target intractable cancer-causing proteins. Credit: Saeed Najafi, ...

Proteins systematically lose their protective hydration shell when their environment becomes more acidic. Until recently, this was just a theory. State-of-the-art imaging techniques have helped ...

A GPS-like technique has been used to track G protein-coupled receptor movement, revealing how these essential receptors function. Although G protein-coupled receptors (GPCRs) are crucial to the ...

Recently, the research team of Prof. WANG Qian from the University of Science and Technology of China (USTC) of the Chinese Academy of Sciences (CAS) and Prof. BAI Fang from ShanghaiTech University ...

In Greek mythology, Proteus, son of Poseidon and prophetic shepherd of sea-beasts, could foretell the future. The elusive sea god was difficult to capture as he assumed many forms—a lion, a serpent, ...

The genetic code has given rise to the enormous diversity of proteins we see in nature—and rearranging the order of codons that make up a protein’s sequence leads to an immense variety of structure ...

Amyloids are perhaps best known as a key driver of Alzheimer’s disease. The amorphous proteins, found throughout the human body, stick to nerve cells like plaque, choking off their function and ...

Proteins and peptides are the primary functional polymers of medical biochemistry, directing virtually all cellular processes through their structural diversity, catalytic activities and signalling ...