Over the past two decades, researchers have learned that DNA inside the cell nucleus naturally folds into a network of ...

Gene therapy holds the promise of preventing and curing disease by manipulating gene expression within a patient's cells. However, to be effective, the new gene must make it into a cell's nucleus. The ...

Although DNA is tightly packed and protected within the cell nucleus, it is constantly threatened by damage from normal ...

In 1869, Swiss scientist Friedrich Miescher isolated a mysterious substance from cell nuclei—an overlooked finding that would ...

If severe DNA damage is not repaired, the consequences for the health of cells and tissues are dramatic. A study led by ...

For decades, biologists have known that the instructions for life are written in DNA, yet the vast majority of those letters seemed to sit in the dark, doing little that was obvious. Now a new ...

Scientists have recently been learning more about the importance of small bits of circular genetic material known as extrachromosomal DNA (ecDNA). These little circles of DNA can hitch a ride with ...

A new study shows that cancer damages its own DNA by pushing key genes to work too hard. Researchers found that the most ...

As people age, their immune systems deteriorate. This makes them more susceptible to infections and can mean that vaccines ...

Using single-cell epigenomic profiling of immune cells from 110 individuals, researchers show that genetic variation and ...