The new workflow was adapted from an enzymatic DNA tagging technology, DNA-TAG, previously developed in the Devaraj lab. In ...

Gene expression and pathway analysis constitute a critical nexus in modern molecular biology, facilitating the exploration of how genes collectively influence cellular functions and disease processes.

Gene therapy holds the promise of preventing and curing disease by manipulating gene expression within a patient's cells. However, to be effective, the new gene must make it into a cell's nucleus. The ...

New research suggests that alternative splicing may have an even greater influence on biology than just by creating new protein isoforms. The study shows that the biggest impact of alternative ...

Epigenetics, the dynamic regulation of genetic expression, involves complex molecular mechanisms. While the process of gene silencing by methylating the H3K27 position in histones is understood, not ...

Scientists at the MRC Laboratory of Medical Sciences (LMS) have discovered a DNA-based “dimmer switch” that regulates the activity of a critical developmental gene, Cdx2. This work could pave the way ...