A Children's Hospital of Philadelphia (CHOP) research team, working with collaborators across Penn and several national institutions, reported that many critically ill children who develop multiple ...

Sepsis is a complex clinical syndrome characterized by dysregulated immune responses, systemic inflammation, and multi-organ dysfunction. It involves intricate interactions among multiple signaling ...

Hepatorenal syndrome (HRS) is a severe complication of advanced liver disease with high mortality and limited treatment options, often requiring liver or combined liver-kidney transplantation. Current ...

Innate and adaptive immune cells coordinate the excessive inflammatory response known as a cytokine storm in acute respiratory distress syndrome, leading to alveolar–capillary barrier damage, ...

Cardiovascular disease (CVD) remains a leading cause of morbidity and mortality worldwide. A growing body of evidence identifies endothelial dysfunction as ...