The prevailing theory of cancer pathogenesis has been that cancers arise as normal cells gradually acquire somatic mutations, endowing malignant properties. In this framework, cells comprising ...

Cancer begins when mutations in specific genes override the body’s built-in controls on cell division, allowing rogue cells to multiply without restraint. Decades of research have traced this process ...

Myeloproliferative neoplasms (MPNs) are myeloid malignancies characterized by the expansion of a multipotent hematopoietic progenitor stem cell [1, 2]. Philadelphia-negative MPNs in the chronic phase ...

An international team of scientists headed by researchers at the University of Edinburgh, has created a complete map showing how hundreds of possible mutations in a key cancer gene, CTNNB1, influence ...