The Detroit Lions will face the Buffalo Bills on "Thursday Night Football" in Week 2 on Sept. 17 on Prime Video. The full 2026 NFL regular-season schedule will be revealed on Thursday night.

One recently announced game has the Detroit Lions on the road against the Buffalo Bills in Week 2 for the Bills' home opener at the brand-new Highmark Stadium in a Thursday night game. The Cardinals will face the Lions in 2026 at home. It just won't happen in Week 2.

The latest 2026 NFL schedule leak indicates that the Detroit Lions are set to make NFL history in Week 2 of the upcoming season.

Sean Payton, Bo Nix and the reigning AFC West champion Broncos will defend their divisional title in a heavyweight bout against Andy Reid's Chiefs to kick off "Monday Night Football" in 2026. The big

NFL schedule release live updates, tracker, leaks, reports, rumors, speculation and what we know about games during the 2026 NFL regular season.

The Lions are the opponent in Buffalo's home opener.

The Buffalo Bills announced their Week 2 home opponent, which might mark the debut of their new stadium under the lights.

With the full schedule set to be revealed, each team has one key request that could shape its season

The most exciting time of the offseason for some is the release of the NFL schedule. An event that wasn't at one point, the NFL made the schedule week a highly anticipated part of the calendar during a period when the offseason is at a low point.