The New Orleans Saints have an early lead on the first overall pick in the 2026 NFL draft, but barely. There's a lot of football left to be played.

The New Orleans Saints can expect a heavy dose of Carolina Panthers running back Rico Dowdle in Sunday's NFC South matchup.

The New Orleans Saints and Carolina Panthers meet Sunday for a Week 10 game in Charlotte, North Carolina. Kickoff is scheduled for 1 p.m. ET.

Rookie WR Tetairoa McMillan, the Panthers top wide receiver, is expected to play against the Saints in Week 10 after a hamstring scare.

New Orleans Saints offensive coordinator Doug Nussmeier speaks with the media live from the Ochsner Sports Performance Center on Thursday, November 6, 2025 ahead of Week 10 vs. the Carolina Panthers.

The Rams are 5.5-point favorites, according to the latest Rams vs. 49ers odds. The over/under for total points scored is 49.5. The Rams are -255 money line favorites (risk $255 to win $100), and the 49ers are +206 underdogs (wager $100 to win $206).

Carolina falls to the Saints at Bank of America Stadium, dropping them to 5-5 this season. Sunday’s game started hopeful; the Panthers were still riding high from that 16-13 upset over Green Bay on the road.

New Orleans Saints head coach Kellen Moore speaks with the media live from the Ochsner Sports Performance Center on Friday, November 7, 2025 ahead of Week 10 vs. the Carolina Panthers.