You can disable Windows Thumbs.db files from being created using Group Policy or Registry Editor. Stop or prevent Windows from creating Thumbs.db!

Some files such as the Thumbs.db file can be disabled in Windows, so if you have a personal PC with Windows on it (ie, VMWare or Parallels), you can set it to prevent caching of thumbnail previews ...

Thumbs.db is a system file that contains the thumbnail cache–a collection of thumbnail images for photos, documents, Web pages, and so on–for a particular folder.

Windows 11/10 creates thumbs.db files within folders on Network drives & centralized thumbnail cache. Learn how to disable and remove them.