eLife22h
Bridging the Gap in Cancer Cell Behavior Against Matrix Stiffening: Insights from a Trizonal Model
Laboratory for Research on the Structure of Matter (LRSM), University of Pennsylvania, Philadelphia, United States ...
eLife22h
Enalapril mitigates aging by targeting antioxidative genes via phosphorylated Smad1/5/9
In summary, enalapril significantly mitigated multiple pathological markers associated with aging, including lipid droplets, amyloid, glycogen deposition, and fibrosis, in the brain, kidneys, liver, ...
eLife22h
Tissue-specific responses to TFAM and mtDNA copy number manipulation in prematurely ageing mice
This is an important and solid study that examines the role of TFAM, a protein that helps maintain mtDNA, in mtDNA mutator mice. The authors have demonstrated that TFAM's counteractive role in mtDNA ...
eLife22h
Synthetic gene circuits that selectively target RAS-driven cancers
This important study demonstrates the potential of synthetic gene circuits to detect and target aberrant RAS activity in cancer cell lines. The circuit design is novel and the evidence supporting the ...
eLife8h
Beta Cells: Opportunity makes a hub or a leader
Functional subpopulations of β-cells emerge to control pulsative insulin secretion in the pancreatic islets of mice through calcium oscillations.
eLife1d
Identification of a sub-population of synovial mesenchymal stem cells with enhanced treatment efficacy in a rat model of Osteoarthritis
This important study focused on characterizing clonally derived MSC populations from the synovium of normal and osteoarthritis (OA) patients, demonstrating their potential to regenerate cartilage in ...
eLife2d
Megakaryocytes assemble a three-dimensional cage of extracellular matrix that controls their maturation and anchoring to the vascular niche
Megakaryocytes form a three-dimensional (3D) cage composed of laminin and collagen IV connected to the basement membrane surrounding them. This microarchitecture stabilizes megakaryocytes within their ...
eLife5d
Impacts of Structural Properties of Myosin II Filaments on Force Generation
Myosin II plays the most important role in cellular force generation. Myosin II molecules self-assemble into filaments with different structures depending on myosin II isoforms and other conditions ...
eLife8d
Drug combination prediction for cancer treatment using disease-specific drug response profiles and single-cell transcriptional signatures
retriever generates disease-specific transcriptional drug response signatures by merging transcriptional signatures over time, concentration, and cell-type. These signatures can then be matched to ...
eLife7d
HERV activation segregates ME/CFS from fibromyalgia while defining a novel nosologic entity
Abstract Research of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Fibromyalgia (FM), two acquired chronic illnesses affecting mainly females, has failed to ascertain their frequent ...
eLife7d
Targeting SLC7A11-mediated cysteine metabolism for the treatment of trastuzumab resistant HER2 positive breast cancer
This study presents a useful finding that targeting amino acid metabolism can overcome Trastuzumab resistance in HER2+ breast cancer. The evidence supporting the claims of the authors is solid and the ...
eLife9d
Dissecting infant leukemia developmental origins with a hemogenic gastruloid model
This valuable study presents a mouse gastruloid model that can be used to generate hematopoietic progenitors as well as leukemic cells. However, in its current form, the manuscript is inadequate ...