The Tigers should easily get to at least six wins and avoid their worst regular season under coach Dabo Swinney.

The Clemson Tigers (5-5, 4-4 ACC) walked into L&N Federal Credit Union Stadium in desperate need of their fifth win of the season. They left with a 20-19 nail-biting victory over No. 20 Louisville and proof that their team has plenty of fight in them,

LOUISVILLE, Ky. — Adam Randall ran for 105 yards and two touchdowns, and Clemson overcame Louisville’s goal-line stand and a botched punt snap to sneak out with a 20-19 victory over the No. 19 Cardinals on Friday night.

The warm fuzzies of essentially locking up a bowl spot should not overshadow another round of concerning in-game slip-ups.

QB Miller Moss was 19 of 27 passing for 212 yards, no touchdowns, and no interceptions to go with a rushing touchdown. Moss rushed for his 8th TD of the season, tying Benny Russell for 6th most rushing TDs in a season by a quarterback and tying John Madeya for 7th in career rushing TDs by a quarterback.

The Clemson Tigers earned a 20-19 victory over the Louisville Cardinals in Week 12 of the college football season. Here are the highlights:

Louisville starting quarterback Miller Moss placed blame following the team's upset loss to the Clemson Tigers.

In a recent public appearance, Clemson athletic director Graham Neff did not take a firm stance on whether that’s the best way to run a college football program in 2025 — but he did acknowledge there’s “probably a better balance” for Clemson football to strike going forward.

Kickoff from L&N Federal Credit Union Stadium in Louisville, Ky., is at 7:30 p.m. ET. The Cardinals are 1.5-point favorites in the latest Clemson vs. Louisville odds, while the over/under for total points scored is 50.5. Before making any Louisville vs. Clemson picks, check out the college football predictions from the SportsLine Projection Model .

The Clemson Tigers upset the Louisville Cardinals in a Week 12 ACC college football game on the road. Here are the highlights.