Preview the Week 11 matchup between the San Francisco 49ers and Arizona Cardinals with predictions, odds, over/under, spread, betting lines and more.

Without their explosive rookie receiver, the Cardinals' offense faces a significant challenge. The 49ers' battered defense could exploit this crucial void.

Thomas Valentine of Pro Football Focus spotlighted Kittle against Budda Baker as his matchup to watch in the game. While that may scare some 49ers, the analyst highlights why this could end up going in favor of the tight end.

GLENDALE, Ariz. – Linebacker Tatum Bethune quickly nixed any comparisons between Arizona Cardinals tight end Trey McBride and 49ers counterpart George Kittle. “Nah, nah, not at all. George, nobody is similar to George,” Bethune said. “George is a unicorn.”

The Cardinals' Week 11 game against the 49ers will basically only get coverage in the two teams' home viewing markets.

Nov 3, 2025; Arlington, Texas, USA; Arizona Cardinals wide receiver Michael Wilson (14) runs against Dallas Cowboys cornerback DaRon Bland (26) in the first half at AT&T Stadium. Mandatory Credit: Kevin Jairaj-Imagn Images / Kevin Jairaj-Imagn Images

Sunday will be the 2025 debut for Arizona Cardinals outside linebacker BJ Ojulari. Among the roster moves the Cardinals made on Saturday ahead of their Sunday game in Week 11 against the San Francisco 49ers, Ojulari was activated from the PUP (physically unable to perform) reserve.

Here is a quick scouting report for the 49ers on the Cardinals, courtesy of a writer who covers Arizona like a glove.